Medical Community Resources

Scalp Cooling Clinical Studies

Abramov 2011  

Abramov M, Semenova I. Cooling of the scalp to prevent anticancer chemotherapy-induced alopecia. European Journal Cancer 2011;47:S321 (abstract #4245).


Adams 1992  

Adams L, Lawson N, Maxtred KJ, Symonds RP. The prevention of hair loss from chemotherapy by the use of cold-air scalp-cooling. European Journal Cancer Care 1992;1(5):16-18.


American Cancer Society 2015  

American Cancer Society. Cold Caps (Scalp Hypothermia). 2015; Accessed on 16 November 2015 at:


Betticher 2013  

Betticher DC, Delmore G, Breitenstein U, Anchisi S, Zimmerli-Schwa B, Müller A, von Moos R, Hügli-Dayer AM, Schefer H, Bodenmann S, Bühler V, Trueb RR. Efficacy and tolerability of two scalp cooling systems for the prevention of alopecia associated with docetaxel treatment. Support Care Cancer 2013;21:2565-2573.


Breed 2011  

Breed WPM, van den Hurk JG, Peerebooms. Presentation, impact and prevention of chemotherapy-induced hair loss. Expert Review of Dermatology 2011;6(1):109-125.


Choi 2014  

Choi EK, Kim I-R, Chang O, Knag D, Nam S-J, Lee JE, Lee SK, Im Y-H, Park YH, Cho J. Impact of chemotherapy-induced alopecia distress on body image, psychosocial well-being, and depression in breast cancer patients. Psycho-Oncology 2014;23:1103-1110.


Christodoulou 2002  

Christodoulou C, Klouvas G, Efstathiou E, Zervakis D, Papazachariou E, Plyta M, Skarlos DV. Effectiveness of MSC cold cap system in the prevention of chemotherapy-induced alopecia. Oncology 2002;62:97-102.


Dean 1983  

Dean JC, Griffith KS, Cetas TC, Mackel CL, Jones SE, Salmon SE. Scalp hypothermia: A comparison of ice packs and the Kold Kap in the prevention of doxorubicin-induced alopecia. Journal Clinical Oncology 1983;1(1):33-37.


Dougherty 1996  

Dougherty L. Scalp cooling to prevent hair loss in chemotherapy. Cancer Nursing 1996;11:507-509.


Dougherty 2006  

Dougherty L. Comparing methods to prevent chemotherapy-induced alopecia. Cancer Nursing Practice 2006;5(6):25-31.


Edelstyn 1977  

Edelstyn GA, Salmon SE, Griffith KS. Prevention of doxorubicin-induced hair loss with scalp hypothermia. Lancet 1977;310(8031):253-254.


Elkström 2005  

Elkström B, Rosenberg P, Gustavsson A, Johansson B. Scalp cooling to prevent chemotherapy-induced hair loss. SBU- The Swedish Council on Technology Assessment in Health Care 2005;Access on 16 November 2015 at: SBU – scalp cooling to prevent chemotherapy induced hair loss.


Fried 1998  

Fried G, Kuten A, Vizel B, Drumea K, Haim N. Scalp cooling system (Thairapy system) in the prevention of alopecia in adjuvant CMF chemotherapy for breast cancer. European Journal Cancer 1998;34:S42 (abstract # P109).


Friedrichs 2014  

Friedrichs K, Carstensen MH. Successful reduction of alopecia induced by anthracycline and taxane containing adjuvant chemotherapy in breast cancer – clinical evaluation of sensor-controlled scalp cooling. SpringerPlus 2014;3:500.


Giaccone 1988  

Giaccone G, Di Giulio F, Morandini MP, Calciati A. Scalp hypothermia in the prevention of doxorubicin-induced hair loss. Cancer Nursing 1988;11(3):170-173.


GRADEpro 2015  

Accessed on November 28, 2015 at:


Grevelman 2005  

Grevelman EG, Breed WPM. Prevention of chemotherapy-induced hair loss by scalp cooling. Annals of Oncology 2005;16:352-358.


Guy 1982  

Guy R, Parker H, Shah S, Geddes D. Scalp cooling by thermocirculator. Lancet 1982;319(8278):937-938.


Hedges 1985  

Hedges LV, Olkin I. Statistical methods for meta-analysis. 1st edition. New York. Academic Press 1985.


Hesketh 2004  

Hesketh PJ, Batchelor D, Golant M, Lyman GH, Rhodes N, Yardley D. Chemotherapy-induced alopecia: psychosocial impact and therapeutic approaches. Support Care Cancer 2004;12:543-549.


Higgins 2011  

Higgins JPT, Green S. Cochrane Handbook for Systematic Reviews of Interventions. The Cochrane Collaboration 2011;Version 5.1.0 [updated March 2011]:Available from


Hillen 1990  

Hillen HF, Breed WP, Botman CJ. Scalp cooling by cold air for the prevention of chemotherapy-induced alopecia. Netherland Journal Medicine 1990;37:231-235.


Johansen 1985  

Johansen LV. Scalp hypothermia in the prevention of chemotherapy-induced alopecia. Acta Oncologica 1985;24:113-116.


Katsimbri 2000  

Katsimbir P, Bamias A, Pavlidis N. Prevention of chemotherapy-induced alopecia using an effective scalp cooling system. European Journal Cancer 2000;36:766-771.


Kennedy 1982  

Kennedy M, Packard R, Grant M, Padilla G, Presant C, Chillar R. The effects of using Chemocap® on occurrence of chemotherapy-induced alopecia. Oncology Nursing Forum 1982;10(1):19-24.


Komen 2011  

Komen MMC, Smorenburg CH, Breed WPM, van den Hurk, CJG, Nortier JW. Optimal pre-infusion cooling time in patients treated with chemotherapy and scalp cooling. European Journal Cancer 2011;47:S320 (abstract #4242).


Komen 2013  

Komen MMC, Smoreenburg CH, van den Hurk CJG, Nortier JWR. Factors influencing the effectiveness of scalp cooling in the prevention of chemotherapy-induced alopecia. The Oncologist 2013;18:885-891.


Lemieux 2008  

Lemieux J, Maunsell E, Provencher L. Chemotherapy-induced alopecia and effects on quality of life among women with breast cancer: a literature review. Psycho-Oncology 2008;17:317-328.


Lemieux 2009  

Lemieux J, Amireault C, Provencher L, Maunsell E. Incidence of scalp metastases in breast cancer: a retrospective cohort study in women who were offered scalp cooling. Breast Cancer Research and Treatment 2009;118:547-552.


Lemieux 2015        

Lemieux J, Provencher L, Perron L, Brisson J, Amireault C, Blanchette C, Maunsell E. No effect of scalp cooling on survival among women with breast cancer. Breast Cancer Research and Treatment 2015;149:263-268.


Lofti-Jam 2008  

Lofti-Jam K, Carey M, Jefford M, Schofield P, Charleson C, Aranda S. Nonpharmacologic strategies for managing common chemotherapy adverse effects: A systematic review. Journal Clinical Oncology 2008;26(34):5618-5629.


Lovejoy 1979  

Lovejoy NC. Preventing hair loss during adriamycin therapy. Cancer Nursing 1979;2(2):117-121.


MacDuff 2003  

Macduff C, Mackenzie T, Hutcheon A, Melville L, Archibald H. The effectiveness of scalp cooling in preventing alopecia for patients receiving epirubicin and docetaxel. European Journal Cancer Care 2003;12:154-161.


Massey 2004  

Massey CS. A multicentre study to determine the efficacy and patient acceptability of the Paxman Scalp Cooler to prevent hair loss in patients receiving chemotherapy. European Journal Oncology Nursing 2004;8:121-130.


Maxwell 1980  

Maxwell MB. Scalp tourniquets for chemotherapy-induced alopecia. Journal of Nursing 1980;80(5):900-903.


Moher 2009  

Moher D, Liberati A, Tetzlaff J, Altman DG, The PRISMA Group. Preferred reporting items for systematic reviews and meta-analyses: The PRISMA statement. PLoS Med 2009;6(6):e10000097. doi:10.1371/journal.pmed10000097.


Mols 2009  

Mols F, van den Hurk CJG, Vingerhoets AJJM. Scalp cooling to prevent chemotherapy-induced hair loss: practical and clinical consideration. Support Care Cancer 2009;17:181-9.


NCT01831024 2015  

Rugo HS, Klein P, Melin SA, Hurvitz SA, Melisko ME, Moore A, Park GD, Bågeman E, D’Agostino RB, Ver Hoeve ES, Esserman L, Cigler T. Prevention of chemotherapy-induced alopecia with scalp cooling. NCT01831024Accessed on November 27, 2015 at:


NCT01986140 2015.  Assessed on November 29, 2015 at:


Parker 1987  

Parker R. The effectiveness of scalp hypothermia in preventing cyclophosphamide-induced alopecia. Oncology Nursing Forum 1987;14(6):49-53.


Poder 2011  

Poder TG, He J, Lemieux R. Effectiveness of scalp cooling in chemotherapy. Bulletin du Cancer 2011;98(9):1119-1129.


Protiere 2002  

Portiere C, Evans K, Camerlo J, d’Ingrado M, Macquart-Moulin G, Viens P, Maraninchi D, Genre D. Efficacy and tolerance of a scalp-cooling system for prevention of hair loss and the experience of breast cancer patients treated with adjuvant chemotherapy. Support Care Cancer 2002;10:529-537.


Ridderheim 2003  

Ridderheim M, Bjurberg M, Gustavsson A. Scalp hypothermia to prevent chemotherapy-induced alopecia is effective and safe: a pilot study of a new digitized scalp-cooling system used in 74 patients. Support Care Cancer 2003;11:371-377.


Ron 1997  

Ron I, Kalmus Y, Kalmus Z, Inbar M, Chaitchik S. Scalp cooling in the prevention of alopecia in patients receiving depilating chemotherapy. Supportive Care in Medicine 1997;5:136-138.


Satterwhite 1984  

Satterwhite B, Zimm S. The use of scalp hypothermia in the prevention of doxorubicin-induced hair loss. Cancer 1984;54:54-57.


Shin 2014  

Shin H, Jo SJ, Kim DH, Kwon O, Myung S-K. Efficacy of interventions for prevention of chemotherapy-induced alopecia: A systematic review and meta-analysis. International Journal of Cancer 2014;136:E442-E454.


Song 2010  

Song F, Parekh S, Hooper L, Loke YK, Ryder J, Sutton AJ, Kwok CS, Pang C, Harvey I. Dissemination and publication of research findings: an updated review of related biases. Health Technology Assessment 2010;14(8):1-193.


Spaeth 2008  

Spaeth D, Luporsi E, Weber B. Efficacy and safety of cooling helmets (CH) for the prevention of chemotherapy-induced alopecia (CIA): a prospective study of 911 patients. Journal Clinical Oncology 2008;26(20 Suppl):9654.


Tachi 2015  

Tachi T, Teramanchi H, Tanaka K, Asano S, Osawa T, Kawashima A, Yasuda M, Mizui T, Nakada T, Noguchi Y, Tsuchiya T, Goto C. The impact of outpatient chemotherapy-related adverse events on the quality of life of breast cancer patients. PLOS One 2015;10(4):e0124169. doi:10.1371/journal.pone.0124169.


Tollenaar 1994  

Tollenaar RA, Liefers GJ, Reelaer van Driel OJ, van de Velde CJ. Scalp cooling has no place in the prevention of alopecia in adjuvant chemotherapy for breast cancer. European Journal Cancer 1994;30A(10):1448-1453.


van den Hurk 2013  

van den Hurk CJG, van den Akker-van Marle ME, Breed WPM, van de Poll-Franse LV, Norteri JWR, Coebergh JWW. Impact of scalp cooling on chemotherapy-induced alopecia, wig use and hair growth of patients with cancer. European Journal of Oncology Nursing 2013;17(5):536-540.


van den Hurk 2013(2)  

van den Hurk CJG, Komen MMC, Norteri JWR, Goey SH, Breed WPM. Short post-infusion scalp cooling time still prevents docetaxel induced alopecia. European Journal Cancer 2013;49:S273.


van den Hurk 2013(3)  

van den Hurk CJG, van de Poll-Franse LV, Breed WPM, Coebergh JWW, Nortier JWR. Scalp cooling to prevent alopecia after chemotherapy can be considered safe in patients with breast cancer. The Breast 2013;22:1001-1004.


van den Hurk 2014  

van den Hurk CJ, van den Akker-van Malre ME, Breed WP, van de Poll-Franse LV, Nortier JW, Coebergh JW. Cost-effectiveness analysis of scalp cooling to reduce chemotherapy-induced alopecia. Acta Oncologica 2014;53(1):80-87.


van den Hurk 2014(2)  

van den Hurk CJG, van den Akker-van Marle ME, Breed WP, van de Poll-Franse LV, Nortier JW, Coebergh JW. Cost-effectiveness analysis of scalp cooling to reduce chemotherapy-induced alopecia. Acta Oncologica 2014;53:80-7.


Wheelock 1984  

Wheelock JB, Myers MB, Krebs HB, Goplerud DR. Ineffectiveness of scalp hypothermia in the prevention of alopecia in patients treated with doxorubicin and cisplatin combinations. Cancer Treatment Reports 1984;68:1387-1388.


Wills 2009  

Wills S, Ravipati A, Nguyen M, Dana Z, Jaiyesimi I, Margolis J, Decker D. Scalp hypothermia minimizes alopecia in breast cancer patients receiving non-anthracycline adjuvant chemotherapy. Journal Cancer Research 2009;doi: 10.1158/0008-5472.SABCS-09-5040.